Interactive diagnostic navigator for mature B-cell lymphoproliferative disorders — structured around CD5 and CD10 expression as primary branching criteria.
⚠ Educational tool only. Based on classic immunophenotypic patterns from haematopathology references. Not intended for clinical diagnosis. Always integrate morphology, genetics, clinical context, and consult a haematopathologist for case-specific interpretation.
Entry — Step 01
Is the B-cell population CD5 positive?
Most common branching point in flow cytometric analysis of mature B-cell LPDs. Aberrant CD5 expression on B-cells is the key discriminator between two major diagnostic streams.
Clinical notes
DLBCL can emerge in any branch — CD5+ subtype exists and carries worse prognosis.
Always correlate with morphology and additional IHC: Cyclin D1, SOX11, LEF1, BCL6, MYC.
MYD88 L265P is present in ~90–95% of LPL but rare in MZL — a critical discriminator.
Some DLBCL cases require gene expression profiling (GCB vs. ABC subtyping) for definitive classification.
HCL-variant and splenic MZL can share features; BRAF V600E strongly favours classic HCL.